Signal Transduction Reagents and Kits
Enzo Life Sciences SB203580, (1mg), CAS Number: 152121-47-6
Protein kinase inhibitor. Cell permeable, specific inhibitor of p38 (SAPK2a). Inhibits p38 MAPK stimulation of MAPKAPK2 (IC.The concentrations of SB203580 required to block Akt phosphorylation (IC50= 3-5µM) are only approximately 10-fold higher than those required to inhibit p38 MAP kinase (IC50=0.3-0.5µM). These data define a new activity for this drug and suggest that extreme caution should be used when interpreting data when SB203580 has been used at concentrations above 1-2µM. Non-specific effects include inhibition of COX-1 and -2. Enhances clonal growth of skin epithelial progenitor cells and stimulates neural stem cell proliferation. Alternative Name: 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole. Formula: C21H16N3FOS. MW: 377.4. CAS Number: 152121-47-6. Purity: ≥97% (HPLC). Appearance: White to off-white powder. Solubility: Soluble in DMSO (50mg/ml). Long Term Storage: -20°C
Selleck Chemical LLC SB202190 (FHPI) 25mg 152121-30-7
SB202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38?/? with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo. SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1. SB202190 significantly suppresses Erastin?dependent ferroptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Echelon Biosciences Research Labs SHUTTLE PIP KIT PI(5)P
Echelon Biosciences - Shuttle PIP Kit - P-9005 - PI(5)P This item is non returnable
Sigma Aldrich Fine Chemicals Biosciences Calpeptin >=98% (HPLC) | 117591-20-5 | MFCD00155623 | 5MG
Calpeptin >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 362.46 | 117591-20-5 | MFCD00155623 | 5MG
Akoya Biosciences TSA Cyanine 5 Reagent Pack 50-150 Slides
TSA Cyanine 3 (Cy3) reagent pack, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. These reagents amplify by depositing extra Cy5 in the localized area of the probe or antibody.
Echelon Biosciences Research Labs PI(4)P DIC8 AMMONIUM 100 ug
Phosphatidylinositol 4-phosphate diC8 (PI(4)P diC8) is a synthetic, purified dioctanoyl PI(4)P.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4-phosphate (PI(4)P) is the biosynthetic precursor to PI(4,5)P2 and has an important roles in regulating sphingomyelin and glycosphingolipid metabolism and membrane trafficking at the exit of the Golgi complex. This item is non returnable
Echelon Biosciences Research Labs 3S-PTDINS(3,4,5)P3 DIC16 500 ug
PtdIns(3,4,5)P3 3-phosphothioate, diC16 (3S-PtdIns(3,4,5)P3, diC16) is a water-soluble, synthetic PI(3,4,5)P3 analog in which the 3-phosphate has been rendered metabolically stable as a phosphorothioate. P-3S908 shows 90% inhibition of PTEN at 0.4M. This item is non returnable
Medchemexpress LLC HY-112815 5mg Medchemexpress, ALK2-IN-2 CAS:2254409-25-9 Purity:>98%
Medchemexpress, HY-112815 5mg ALK2-IN-2 CAS:2254409-25-9 ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) with an IC50 of 9 nM, and over 700-fold selectivity against ALK3. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Echelon Biosciences Research Labs 1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP) 10 mg
1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP or HMBPP) is an intermediate in the non-mevalonate pathway and is biosynthesized from 2-C-Methyl-D-erythritol 2,4-cyclophosphate (cMEPP) by IspG (GcpE). It is the substrate for IspH (LytB) yielding IPP and DMAPP. In addition, HDMAPP is the most potent VgVd T-cell activator identified. This item is non returnable
Echelon Biosciences Research Labs EICOSANOYL LPA 1 mg
Arachidoyl LPA, 20:0 LPA (aka Eicosanoyl LPA) is an analog of lysophosphatidic acid (LPA), a lysophospholipid involved in cell proliferation. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation, chemotaxis, platelet aggregation, wound healing, angiogenesis, tumor invasion, and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer, LPA primarily promotes cell survival, migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer. This item is non returnable
Sigma Aldrich Fine Chemicals Biosciences Zolmitriptan Related Compound H United States Pharmacopeia (USP) Reference Standard | 1116-77-4 | MFCD00671479 | 50MG
Zolmitriptan Related Compound H United States Pharmacopeia (USP) Reference Standard | Mol Wt: 189.3 | 1116-77-4 | MFCD00671479 | 50MG
Medchemexpress LLC Syk-IN-4 | 2932264-95-2 | 98.0% | C21H25N9O | 10MG
Potent, selective, orally bioavailable spleen tyrosine kinase (SYK) inhibitor with sub-nanomolar potency (IC50 = 0.31 nM). Characterized for in vivo oral exposure and intended for research into autoimmune disorders and hematologic cancers. Supplied as a high-purity white to off-white solid with documented solubility and storage recommendations.
- Sub-nanomolar inhibitory potency against SYK (IC50 = 0.31 nM).
- Orally bioavailable with demonstrated oral exposure in rodent models.
- High purity suitable for biochemical and cellular assays.
- Well-characterized solubility protocols for in vivo formulation.
- Stable under recommended storage conditions.